pentobarbital will decrease the level or result of saxagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.
pentobarbital will reduce the extent or impact of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
CYP3A4 inducers could enhance the metabolism of clopidogrel to its Energetic metabolite. Check patients for prospective boost in antiplatelet effects when CYP3A4 inducers are made use of together with clopidogrel
pentobarbital will reduce the level or outcome of phenytoin by influencing hepatic enzyme CYP2C9/10 metabolism. Use Caution/Check.
pentobarbital will minimize the level or influence of estradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital improves toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers could raise the metabolism of ifosfamide to its active alkylating metabolites.
pentobarbital will lessen the level or impact of verapamil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
lasmiditan, pentobarbital. Both improves effects of another by sedation. Use Warning/Keep track of. Coadministration of lasmiditan and other CNS depressant drugs, including here Liquor have not been evaluated in medical studies. Lasmiditan may induce sedation, and other cognitive and/or neuropsychiatric adverse reactions.
Avoid; coadministration with CYP3A inducers might result in diminished plasma concentrations of elvitegravir and/or a concomitantly administered protease inhibitor and bring about lack of therapeutic influence also to attainable resistance
pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Warning/Monitor. Drugs that boost delta-aminolevulinic acid synthetase may perhaps reduce hemin influence.
pentobarbital will minimize the extent or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known.
With therapeutic doses of TCAs, barbiturates increase metabolism and reduce blood concentrations of TCAs.
Premature infants are particularly susceptible to the depressant effects of barbiturates; if barbiturates are applied all through labor and supply, resuscitation devices really should be readily available
pentobarbital will minimize the level or impact of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.